Exploring the associations between drug side-effects and therapeutic indications
نویسندگان
چکیده
منابع مشابه
Exploring the Relationship Between Drug Side-Effects and Therapeutic Indications
Therapeutic indications and drug side-effects are both measureable human behavioral or physiological changes in response to the treatment. In modern drug development, both inferring potential therapeutic indications and identifying clinically important drug side-effects are challenging tasks. Previous studies have utilized either chemical structures or protein targets to predict indications and...
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Inferring potential therapeutic indications and identifying clinically important side-effects are both important and challenging tasks in modern drug development. Previous studies have utilized drug chemical structures and protein targets to construct predictive models for both tasks. According to our study, the drug therapeutic information itself is highly predictive for side-effects, and drug...
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Previous analysis of systems pharmacology has revealed a tendency of rational drug design in the pharmaceutical industry. The targets of new drugs tend to be close with the corresponding disease genes in the biological networks. However, it remains unclear whether the rational drug design introduces disadvantages, i.e. side effects. Therefore, it is important to dissect the relationship between...
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12 چکیده تفاوت های فردی، به عنوان خصوصیات روانشناختی غالب، باید در سطوح مختلف تدریس و یادگیری زبان کاملاً مورد ملاحظه قرار گیرند. از میان تاثیرگذارترین سازه های روانشناختی که منجر به تفاوت های فردی می شوند، می توان ازهوش چندگانه و منبع کنترل نام برد. هوش چندگانه با جنبه های متفاوتی از هوش سر و کار دارد که ممکن است هر شخص از آن برخوردار باشد. منبع کنترل، به عنوان مفهوم روانشناختی دیگر، به استن...
15 صفحه اولOverlap in drug-disease associations between clinical practice guidelines and drug structured product label indications
BACKGROUND Clinical practice guidelines (CPGs) recommend pharmacologic treatments for clinical conditions, and drug structured product labels (SPLs) summarize approved treatment indications. Both resources are intended to promote evidence-based medical practices and guide clinicians' prescribing decisions. However, it is unclear how well CPG recommendations about pharmacologic therapies match S...
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ژورنال
عنوان ژورنال: Journal of Biomedical Informatics
سال: 2014
ISSN: 1532-0464
DOI: 10.1016/j.jbi.2014.03.014